TAF3

Across TCGA cell cohorts, TAF3 mutation is significantly associated with the RNA expression of many other genes, with 893 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAF3-associated genes across cancer lineages are SMU1, PPP4R3A, and CNOT6. Each is linked with TAF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAF3-to-partner and partner-to-TAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMU1 grouped by TAF3-low versus TAF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF3→partner) and Y-score (partner→TAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMU1 →	+0.421	+2.714	<.001	.002	3	3
LARGE_INTESTINE	PPP4R3A →	+0.500	+2.714	<.001	.002	3	2
LARGE_INTESTINE	CNOT6 →	+0.482	+2.628	.006	.002	3	2
LARGE_INTESTINE	CAAP1 →	+0.590	+3.459	.001	.001	3	2
LARGE_INTESTINE	CDC42EP1 →	+0.829	+2.628	.007	.002	3	2
LARGE_INTESTINE	ZIC5 →	+1.131	+2.459	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 893 associations by consensus.

SMU1 by TAF3 expression — LARGE_INTESTINE

Explore this box plot interactively →