TAF1C

Across TCGA pan-cancer cohorts, TAF1C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TAF1C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TAF1C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TAF1C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where TAF1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAF1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.783	<.001	12	view →
COAD	All	IV	+1.065	<.001	10	view →
THCA	All	II,III,IV	−0.429	<.001	10	view →
KICH	Male	All	−0.950	<.001	7	view →
LIHC	Female	All	+0.680	<.001	7	view →
STAD	Male	II,III,IV	+1.044	<.001	6	view →
BLCA	All	All	+0.558	.005	6	view →
BRCA	Female	All	−0.481	<.001	6	view →
KIRC	Female	All	+0.476	<.001	6	view →
CHOL	Male	All	+2.020	<.001	5	view →
READ	All	All	+0.773	<.001	3	view →
KIRP	All	IV	+1.070	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TAF1C–HNSC

Open the HNSC breakdown →