TADA2A

Across TCGA patient cohorts, TADA2A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TADA2A-associated genes across cancer lineages are EGFR, JNK_pT183_Y185, and MSH2. Each is linked with TADA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TADA2A-to-partner and partner-to-TADA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by TADA2A-low versus TADA2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TADA2A→partner) and Y-score (partner→TADA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.182	-3.169	.005	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-3.169	.011	.019	3	1
UCEC	MSH2 →	-0.333	-3.295	<.001	.009	3	1
UCEC	p62 Lck ligand →	+0.367	+3.000	.006	.001	3	1
UCEC	Rad50 →	-0.214	-1.807	.032	.027	3	1
UCEC	Annexin-1 →	+0.523	+2.341	.016	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR by TADA2A expression — UCEC

Explore this box plot interactively →