TACR3

Across TCGA patient cohorts, TACR3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACR3-associated genes across cancer lineages are eIF4E, eEF2, and JNK2. Each is linked with TACR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TACR3-to-partner and partner-to-TACR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TACR3-low versus TACR3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACR3→partner) and Y-score (partner→TACR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.132	+3.459	.037	.004	3	4
UCEC	eEF2 →	+0.277	+2.321	.028	.033	3	2
UCEC	JNK2 →	+0.268	+2.611	<.001	.005	3	2
UCEC	Notch1 →	+0.190	+1.662	<.001	.011	3	2
UCEC	PCNA →	+0.287	+2.700	<.001	.005	3	2
UCEC	VHL →	-0.792	-1.662	<.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by TACR3 expression — SKCM

Explore this box plot interactively →