TACR3

Across TCGA cell cohorts, TACR3 mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TACR3-associated genes across cancer lineages are AKT inhibitor VIII, MetAP2 Inhibitor, and Kobe2602. Each is linked with TACR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACR3-to-partner and partner-to-TACR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKT inhibitor VIII grouped by TACR3-low versus TACR3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACR3→partner) and Y-score (partner→TACR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AKT inhibitor VIII →	+0.284	+2.859	.020	.024	3	1
SKIN	MetAP2 Inhibitor →	+0.313	+2.863	.006	.023	3	1
SKIN	Kobe2602 →	+0.230	+2.863	.040	.023	3	1
LARGE_INTESTINE	KU-55933 →	+0.376	+2.807	.037	.046	3	1
LARGE_INTESTINE	5-Fluorouracil →	+0.585	+3.184	.025	.007	3	1
LARGE_INTESTINE	Epirubicin →	+0.630	+2.871	.016	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

AKT inhibitor VIII by TACR3 expression — SKIN

Explore this box plot interactively →