TACR2

Across TCGA patient cohorts, TACR2 mutation is significantly associated with the RNA expression of many other genes, with 651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACR2-associated genes across cancer lineages are RN7SKP2, LINC02134, and KCNAB2. Each is linked with TACR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACR2-to-partner and partner-to-TACR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP2 grouped by TACR2-low versus TACR2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACR2→partner) and Y-score (partner→TACR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP2 →	+0.260	+5.912	<.001	.002	3	2
HNSC	LINC02134 →	+0.100	+5.124	<.001	.008	3	2
UCEC	KCNAB2 →	+0.685	+3.928	<.001	<.001	3	2
UCEC	RNU6-728P →	+0.182	+3.220	<.001	.005	3	2
UCEC	RNU6-591P →	+0.150	+5.258	<.001	<.001	3	2
UCEC	MIR521-2 →	+0.268	+2.899	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 651 associations by consensus.

RN7SKP2 by TACR2 expression — HNSC

Explore this box plot interactively →