TACO1

Across TCGA cell cohorts, TACO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,376 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TACO1-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Protein depolymerization. Each is linked with TACO1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TACO1-to-partner and partner-to-TACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by TACO1-low versus TACO1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TACO1→partner) and Y-score (partner→TACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	rRNA 5'-end processing →	+0.111	+0.563	<.001	<.001	3	12
PANCREAS	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.111	+0.563	<.001	<.001	3	12
URINARY_TRACT	Protein depolymerization →	+0.105	+0.639	.003	.007	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of hematopoietic stem cell proliferation →	+0.125	+0.930	<.001	<.001	3	11
SKIN	Positive regulation of pentose-phosphate shunt →	+0.138	+0.495	<.001	.001	3	10
LUNG_SCLC	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.117	+0.463	.001	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,376 associations by consensus.

rRNA 5'-end processing by TACO1 expression — PANCREAS

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