TACC1

Across TCGA pan-cancer cohorts, TACC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TACC1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TACC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TACC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where TACC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.915	0.447	.001	34	view →
PDAC	DFS	Quartile	II,III,IV	0.525	0.255	.002	21	view →
LUAD	DFS	Median	All	0.770	0.493	.004	13	view →
LSCC	OS	Median	All	1.000	0.924	.013	6	view →
UCEC	DFS	Tertile	All	0.969	0.859	.033	4	view →
HNSC	DFS	Quartile	II,III,IV	0.615	0.842	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TACC1–CCRCC (DFS)

Open the CCRCC breakdown →