TACC1

Across TCGA patient cohorts, TACC1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACC1-associated genes across cancer lineages are ATM, eIF4E, and p62 Lck ligand. Each is linked with TACC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TACC1-to-partner and partner-to-TACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TACC1-low versus TACC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC1→partner) and Y-score (partner→TACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.462	-1.986	.001	.008	3	3
UCEC	eIF4E →	+0.183	+3.713	.007	<.001	3	2
UCEC	p62 Lck ligand →	+0.376	+2.000	<.001	<.001	3	2
UCEC	PDCD4 →	-0.479	-2.115	.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.588	+1.522	.002	.017	3	2
UCEC	FoxM1 →	+0.197	+1.459	.019	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by TACC1 expression — UCEC

Explore this box plot interactively →