TAC1

Across TCGA patient cohorts, TAC1 mutation is significantly associated with the RNA expression of many other genes, with 1,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAC1-associated genes across cancer lineages are ABHD17AP9, RNU6-705P, and SLC25A17. Each is linked with TAC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAC1-to-partner and partner-to-TAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD17AP9 grouped by TAC1-low versus TAC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAC1→partner) and Y-score (partner→TAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ABHD17AP9 →	+0.074	+7.640	<.001	.009	3	3
UCEC	RNU6-705P →	+0.725	+2.331	.002	.006	3	2
UCEC	SLC25A17 →	+0.558	+3.470	<.001	.003	3	1
UCEC	PIGH →	+0.587	+3.354	.003	.005	3	1
UCEC	KIAA0586 →	+0.566	+3.202	<.001	.009	3	1
UCEC	SMCHD1 →	+0.843	+3.470	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

ABHD17AP9 by TAC1 expression — BLCA

Explore this box plot interactively →