TAC1

Across TCGA patient cohorts, TAC1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAC1-associated genes across cancer lineages are Heregulin, Tuberin, and beta-Catenin. Each is linked with TAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAC1-to-partner and partner-to-TAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by TAC1-low versus TAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAC1→partner) and Y-score (partner→TAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.156	-3.169	.015	.019	3	1
UCEC	Tuberin →	+0.323	+2.817	.022	.036	3	1
UCEC	beta-Catenin →	+0.640	+3.321	.015	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.733	+2.827	.018	.035	3	1
UCEC	14-3-3_beta →	-0.120	-3.308	.022	.010	2	1
UCEC	p70-S6K_pT389 →	-0.263	-2.990	.008	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Heregulin by TAC1 expression — UCEC

Explore this box plot interactively →