TAB3

Across TCGA pan-cancer cohorts, TAB3 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TAB3 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TAB3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAB3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCS, UCEC, and HNSC are the cancer types where TAB3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	All	0.102	0.688	<.001	36	view →
UCEC	DFS	Median	All	0.955	0.821	.003	36	view →
HNSC	OS	Median	III,IV	0.158	0.628	.005	33	view →
COAD	DFS	Median	II,III,IV	0.293	0.670	<.001	13	view →
ESCA	DFS	Median	II,III,IV	0.089	0.522	.001	12	view →
LUSC	OS	Median	II,III,IV	0.178	0.736	<.001	12	view →
TGCT	DFS	Median	All	0.014	0.837	<.001	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
SKCM	OS	Median	All	0.339	0.784	.021	3	view →
LUAD	OS	Median	All	1.000	0.301	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TAB3–UCS (OS)

Open the UCS breakdown →