TAB3

Across TCGA patient cohorts, TAB3 mutation is significantly associated with the RNA expression of many other genes, with 4,356 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAB3-associated genes across cancer lineages are IL21, FLCN, and SKA1. Each is linked with TAB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TAB3-to-partner and partner-to-TAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by TAB3-low versus TAB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAB3→partner) and Y-score (partner→TAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL21 →	+0.077	+1.583	<.001	<.001	3	4
UCEC	FLCN →	+0.368	+2.273	<.001	<.001	3	3
UCEC	SKA1 →	+0.563	+1.436	<.001	<.001	3	3
UCEC	SNRNP25 →	+0.337	+1.501	<.001	<.001	3	3
UCEC	TPP1 →	+0.347	+1.315	<.001	<.001	3	3
UCEC	TBC1D13 →	+0.295	+2.233	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,356 associations by consensus.

IL21 by TAB3 expression — UCEC

Explore this box plot interactively →