TAB3

Across TCGA cell cohorts, TAB3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TAB3-associated genes across cancer lineages are CCER1, BTNL2, and C18orf63. Each is linked with TAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAB3-to-partner and partner-to-TAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCER1 grouped by TAB3-low versus TAB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAB3→partner) and Y-score (partner→TAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCER1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	BTNL2 →	+0.109	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	C18orf63 →	+0.016	+5.452	<.001	<.001	3	1
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	1
SKIN	FAM71C →	+0.015	+4.510	<.001	.001	3	1
SKIN	CDR1 →	+0.203	+3.920	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CCER1 by TAB3 expression — LARGE_INTESTINE

Explore this box plot interactively →