TAB1

Across TCGA patient cohorts, TAB1 mutation is significantly associated with the RNA expression of many other genes, with 2,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAB1-associated genes across cancer lineages are IGHD1-26, LINC02053, and RN7SL237P. Each is linked with TAB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAB1-to-partner and partner-to-TAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD1-26 grouped by TAB1-low versus TAB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAB1→partner) and Y-score (partner→TAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD1-26 →	+0.399	+2.221	<.001	.005	3	3
HNSC	LINC02053 →	+0.071	+5.505	<.001	.004	3	2
UCEC	RN7SL237P →	+0.218	+1.993	<.001	<.001	3	2
CESC	MIR1827 →	+0.613	+5.306	<.001	.006	3	2
HNSC	CICP6 →	+0.021	+5.124	<.001	.008	3	2
HNSC	RN7SL35P →	+0.206	+5.303	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,234 associations by consensus.

IGHD1-26 by TAB1 expression — UCEC

Explore this box plot interactively →