TAB1

Across TCGA patient cohorts, TAB1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAB1-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and PCNA. Each is linked with TAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAB1-to-partner and partner-to-TAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TAB1-low versus TAB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAB1→partner) and Y-score (partner→TAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+2.807	.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-2.321	.001	.005	3	2
UCEC	PCNA →	+0.230	+2.459	.003	.018	3	2
UCEC	STAT3_pY705 →	-0.339	-2.311	<.001	.005	3	2
UCEC	Chk2_pT68 →	-0.142	-2.312	.034	.034	3	2
UCEC	Cyclin-B1 →	+0.539	+3.584	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by TAB1 expression — UCEC

Explore this box plot interactively →