TAB1

Across TCGA cell cohorts, TAB1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAB1-associated genes across cancer lineages are C6orf118, ITGAD, and ACSM6. Each is linked with TAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAB1-to-partner and partner-to-TAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by TAB1-low versus TAB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAB1→partner) and Y-score (partner→TAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	IFIT1B →	+0.033	+3.823	.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C6orf118 by TAB1 expression — LARGE_INTESTINE

Explore this box plot interactively →