TAAR5

Across TCGA pan-cancer cohorts, TAAR5 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated TAAR5 data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TAAR5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TAAR5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

CESC, BRCA, and COAD are the cancer types where TAAR5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	III,IV	0.170	0.676	.004	96	view →
BRCA	DFS	Tertile	All	0.843	0.951	<.001	48	view →
COAD	OS	Tertile	II,III,IV	0.133	0.788	.002	45	view →
KICH	OS	Tertile	II,III,IV	0.093	0.841	<.001	45	view →
KIRC	DFS	Tertile	All	0.691	0.846	.001	42	view →
MESO	OS	Tertile	All	0.174	0.562	.005	27	view →
ACC	DFS	Tertile	II,III,IV	0.242	0.724	.034	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
UCEC	DFS	Tertile	II,III,IV	0.844	0.702	.042	12	view →
LGG	OS	Quartile	All	0.980	0.883	.008	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TAAR5–CESC (OS)

Open the CESC breakdown →