TAAR2

Across TCGA patient cohorts, TAAR2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAAR2-associated genes across cancer lineages are Shc_pY317, MEK1, and mTOR_pS2448. Each is linked with TAAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAAR2-to-partner and partner-to-TAAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TAAR2-low versus TAAR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAAR2→partner) and Y-score (partner→TAAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.160	-3.321	.043	.010	3	2
UCEC	MEK1 →	+0.422	+2.999	.027	.035	3	1
UCEC	mTOR_pS2448 →	-0.186	-2.980	.017	.036	3	1
UCEC	Notch1 →	+0.213	+2.820	.003	.035	3	1
UCEC	PCNA →	+0.292	+3.321	.009	.010	3	1
UCEC	TIGAR →	+0.251	+2.196	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Shc_pY317 by TAAR2 expression — UCEC

Explore this box plot interactively →