Across TCGA patient cohorts, SZT2 mutation is significantly associated with the total protein of many other genes, with 126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SZT2-associated genes across cancer lineages are Cyclin-E2, eEF2, and ACVRL1. Each is linked with SZT2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SZT2-to-partner and partner-to-SZT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SZT2→partner) and Y-score (partner→SZT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.261	+2.190	<.001	.030	3	7
STAD	eEF2 →	+0.499	+3.169	<.001	.018	3	4
BLCA	ACVRL1 →	-0.214	-3.889	.006	<.001	3	4
BLCA	Chk2 →	+0.342	+1.999	<.001	.027	3	4
UCEC	p38-MAPK →	-0.077	-0.846	.029	.039	3	4
COAD	ASNS →	+0.357	+1.371	.004	.023	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

Exploration

SZT2 survival (RNA) · tumor vs normal (RNA) · all SZT2 data types