Across TCGA cell cohorts, SZT2 mutation is significantly associated with the RNA expression of many other genes, with 1,284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SZT2-associated genes across cancer lineages are DCAKD, HSCB, and ALDH6A1. Each is linked with SZT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SZT2-to-partner and partner-to-SZT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SZT2→partner) and Y-score (partner→SZT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCAKD →	+0.609	+3.614	<.001	<.001	3	3
LARGE_INTESTINE	HSCB →	+0.592	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	ALDH6A1 →	+0.971	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	BBS7 →	+0.579	+2.584	<.001	.001	3	3
LARGE_INTESTINE	ZNF721 →	+0.638	+2.129	<.001	.001	3	3
LARGE_INTESTINE	HSF2 →	+0.448	+3.257	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,284 associations by consensus.

Exploration

SZT2 survival (RNA) · tumor vs normal (RNA) · all SZT2 data types