Across TCGA cell cohorts, SZT2 mutation is significantly associated with the mutation status of many other genes, with 6,716 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SZT2-associated genes across cancer lineages are VPS13B, NUMA1, and RELN. Each is linked with SZT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SZT2-to-partner and partner-to-SZT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SZT2→partner) and Y-score (partner→SZT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VPS13B →	+4.000	+3.087	.008	.008	1	6
STOMACH	NUMA1 →	+4.440	+3.415	.001	.001	1	6
OVARY	RELN →	+2.204	+2.791	.005	.005	1	6
BLOOD_Leukemia	TECPR2 →	+3.544	+2.662	<.001	<.001	1	6
UPPER_AERODIGESTIVE_TRACT	CKAP5 →	+5.193	+4.539	<.001	<.001	1	6
LARGE_INTESTINE	AFF3 →	+3.280	+2.341	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,716 associations by consensus.

Exploration

SZT2 survival (RNA) · tumor vs normal (RNA) · all SZT2 data types