SYTL5

Across TCGA patient cohorts, SYTL5 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYTL5-associated genes across cancer lineages are Caspase-7-cleavedD198, Gab2, and Notch1. Each is linked with SYTL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYTL5-to-partner and partner-to-SYTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SYTL5-low versus SYTL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL5→partner) and Y-score (partner→SYTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.549	+1.827	.007	.015	3	3
UCEC	Gab2 →	+0.275	+1.440	.026	.024	3	2
UCEC	Notch1 →	+0.149	+2.070	.002	.001	3	2
UCEC	Rad50 →	-0.218	-3.156	.009	.018	3	2
UCEC	TFRC →	+0.465	+1.736	.011	.007	3	2
UCEC	Tuberin →	+0.218	+1.736	.020	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by SYTL5 expression — UCEC

Explore this box plot interactively →