SYTL4

Across TCGA pan-cancer cohorts, SYTL4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYTL4 data layer compared with 25 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYTL4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SYTL4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, SCLC, and LIHC are the cancer types where SYTL4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.790	0.628	.003	36	view →
SCLC	DFS	Median	All	0.164	0.566	.029	6	view →
LIHC	DFS	Median	All	0.101	0.526	.047	3	view →
COAD	DFS	Median	All	1.000	0.775	.032	3	view →
SKCM	DFS	Median	III,IV	0.121	0.654	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYTL4–UCEC (DFS)

Open the UCEC breakdown →