SYTL4

Across TCGA pan-cancer cohorts, SYTL4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SYTL4 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SYTL4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYTL4 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

LSCC, CCRCC, and COAD are the cancer types where SYTL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.514	0.990	.001	44	view →
CCRCC	DFS	Quartile	All	0.340	0.970	.002	26	view →
COAD	DFS	Median	III,IV	1.000	0.891	.040	12	view →
UCEC	OS	Quartile	III,IV	0.250	1.000	.027	8	view →
LUAD	DFS	Quartile	III,IV	0.276	0.769	.013	6	view →
HNSC	OS	Quartile	II,III,IV	0.922	1.000	.021	4	view →
PDAC	DFS	Median	All	0.265	0.421	.040	2	view →
GBM	DFS	Quartile	All	0.570	0.834	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SYTL4–LSCC (DFS)

Open the LSCC breakdown →