SYTL3

Across TCGA patient cohorts, SYTL3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYTL3-associated genes across cancer lineages are eIF4E, FoxM1, and JNK_pT183_Y185. Each is linked with SYTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYTL3-to-partner and partner-to-SYTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SYTL3-low versus SYTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL3→partner) and Y-score (partner→SYTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.165	+3.335	.012	.005	3	2
UCEC	FoxM1 →	+0.217	+2.331	.007	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.139	-1.340	.008	.015	3	2
UCEC	mTOR_pS2448 →	-0.147	-2.643	.001	<.001	3	2
UCEC	p27_pT198 →	+0.103	+3.087	.002	<.001	3	2
UCEC	Annexin-1 →	+0.361	+1.505	.029	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by SYTL3 expression — UCEC

Explore this box plot interactively →