SYTL2

Across TCGA patient cohorts, SYTL2 mutation is significantly associated with the RNA expression of many other genes, with 5,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYTL2-associated genes across cancer lineages are GLRX5, TMEM269, and LINC02558. Each is linked with SYTL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYTL2-to-partner and partner-to-SYTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by SYTL2-low versus SYTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL2→partner) and Y-score (partner→SYTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5 →	+0.333	+1.617	<.001	<.001	3	4
LUAD	TMEM269 →	+0.331	+3.376	<.001	.004	3	4
CESC	LINC02558 →	+0.152	+2.932	<.001	.009	3	4
SKCM	HMG20B →	+0.414	+1.452	.003	.003	3	4
UCEC	RITA1 →	+0.361	+1.493	<.001	<.001	3	4
LUAD	EME1 →	+0.719	+3.807	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,707 associations by consensus.

GLRX5 by SYTL2 expression — UCEC

Explore this box plot interactively →