SYTL2

Across TCGA cell cohorts, SYTL2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYTL2-associated genes across cancer lineages are RIT2, PABPC1L2A, and IFNW1. Each is linked with SYTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYTL2-to-partner and partner-to-SYTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by SYTL2-low versus SYTL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL2→partner) and Y-score (partner→SYTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.040	+6.022	<.001	.001	3	1
SKIN	PABPC1L2A →	+0.047	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	IFNW1 →	+0.012	+3.760	.005	.008	3	1
LUNG_NSCLC_LUAD	DBX2 →	+0.019	+4.857	<.001	.009	3	1
BLOOD_Leukemia	CRYBB3 →	+0.112	+4.152	<.001	.009	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RIT2 by SYTL2 expression — SKIN

Explore this box plot interactively →