SYTL2

Across TCGA cell cohorts, SYTL2 mutation is significantly associated with the mutation status of many other genes, with 1,383 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYTL2-associated genes across cancer lineages are DLG5, NLGN1, and ANKRD12. Each is linked with SYTL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYTL2-to-partner and partner-to-SYTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLG5 grouped by SYTL2-low versus SYTL2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL2→partner) and Y-score (partner→SYTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DLG5 →	+2.969	+3.337	.009	.009	1	4
LUNG_NSCLC_LUAD	NLGN1 →	+3.000	+4.604	.001	.001	1	4
BLOOD_Leukemia	ANKRD12 →	+2.260	+3.101	.002	.002	1	3
BLOOD_Leukemia	LTBP1 →	+3.108	+3.108	.008	.008	1	3
BLOOD_Leukemia	FLYWCH1 →	+3.260	+3.498	.001	.001	1	3
BLOOD_Lymphoma	MAGEC3 →	+4.969	+4.014	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,383 associations by consensus.

DLG5 by SYTL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →