SYTL1

Across TCGA pan-cancer cohorts, SYTL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SYTL1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SYTL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SYTL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where SYTL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	1.000	0.774	.002	22	view →
PDAC	OS	Quartile	III,IV	0.240	0.845	.026	9	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	5	view →
GBM	OS	Tertile	All	0.435	0.852	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SYTL1–UCEC (DFS)

Open the UCEC breakdown →