SYTL1

Across TCGA patient cohorts, SYTL1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYTL1-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and EGFR_pY1068. Each is linked with SYTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYTL1-to-partner and partner-to-SYTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SYTL1-low versus SYTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL1→partner) and Y-score (partner→SYTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.129	+1.906	.009	.015	3	2
UCEC	14-3-3_beta →	-0.115	-1.880	<.001	.014	3	1
UCEC	EGFR_pY1068 →	-0.233	-1.440	.007	.024	3	1
UCEC	JNK2 →	+0.231	+2.710	<.001	.003	3	1
UCEC	Ku80 →	+0.185	+1.453	.023	.015	3	1
UCEC	MEK1 →	+0.444	+2.459	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

C-Raf by SYTL1 expression — UCEC

Explore this box plot interactively →