SYTL1

Across TCGA cell cohorts, SYTL1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYTL1-associated genes across cancer lineages are OR2M3, OR10G2, and VSIG4. Each is linked with SYTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYTL1-to-partner and partner-to-SYTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M3 grouped by SYTL1-low versus SYTL1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL1→partner) and Y-score (partner→SYTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR2M3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR10G2 →	+0.033	+4.906	<.001	.006	3	1
LARGE_INTESTINE	VSIG4 →	+0.036	+4.054	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	DPRX →	+0.030	+4.867	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR2M3 by SYTL1 expression — OESOPHAGUS

Explore this box plot interactively →