SYT7

Across TCGA pan-cancer cohorts, SYT7 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SYT7’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SYT7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SYT7 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where SYT7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.656	<.001	8	view →
LSCC	All	All	+0.403	.001	5	view →
PDAC	All	IV	−1.057	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SYT7–LUAD

Open the LUAD breakdown →