SYT6

Across TCGA patient cohorts, SYT6 mutation is significantly associated with the RNA expression of many other genes, with 2,565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT6-associated genes across cancer lineages are RAB11A, UBE3A, and RAD23B. Each is linked with SYT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT6-to-partner and partner-to-SYT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB11A grouped by SYT6-low versus SYT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT6→partner) and Y-score (partner→SYT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB11A →	+0.419	+2.576	<.001	<.001	3	3
UCEC	UBE3A →	+0.472	+2.263	<.001	<.001	3	3
UCEC	RAD23B →	+0.511	+2.513	<.001	<.001	3	3
UCEC	NDFIP1 →	+0.364	+1.652	.004	.006	3	3
UCEC	GCH1 →	+0.633	+2.295	<.001	<.001	3	3
UCEC	ALG10 →	+0.352	+1.847	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,565 associations by consensus.

RAB11A by SYT6 expression — UCEC

Explore this box plot interactively →