SYT6

Across TCGA cell cohorts, SYT6 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT6-associated genes across cancer lineages are RGSL1, ZNF831, and LCN9. Each is linked with SYT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT6-to-partner and partner-to-SYT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGSL1 grouped by SYT6-low versus SYT6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT6→partner) and Y-score (partner→SYT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RGSL1 →	+0.030	+5.459	<.001	<.001	3	1
CNS	ZNF831 →	+0.070	+3.832	<.001	.005	3	1
CNS	LCN9 →	+0.129	+4.285	.003	.001	3	1
CNS	DCD →	+0.022	+4.772	<.001	.002	3	1
CNS	CYP2C19 →	+0.040	+4.449	.008	.001	3	1
CNS	AGTR2 →	+0.032	+3.643	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

RGSL1 by SYT6 expression — CNS

Explore this box plot interactively →