SYT5

Across TCGA patient cohorts, SYT5 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT5-associated genes across cancer lineages are PAI-1, EGFR_pY1068, and eIF4E. Each is linked with SYT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT5-to-partner and partner-to-SYT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by SYT5-low versus SYT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT5→partner) and Y-score (partner→SYT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.342	+3.459	.022	.005	3	2
UCEC	EGFR_pY1068 →	-0.275	-2.807	.012	.003	3	1
UCEC	eIF4E →	+0.213	+2.115	.020	.019	3	1
UCEC	MEK1 →	+0.553	+3.584	<.001	.002	3	1
UCEC	MSH2 →	-0.283	-2.115	.005	.019	3	1
UCEC	Notch1 →	+0.175	+2.807	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PAI-1 by SYT5 expression — UCEC

Explore this box plot interactively →