Across TCGA patient cohorts, SYT3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT3-associated genes across cancer lineages are PCNA, TIGAR, and ATM. Each is linked with SYT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT3-to-partner and partner-to-SYT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT3→partner) and Y-score (partner→SYT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.281	+3.169	<.001	<.001	3	3
UCEC	TIGAR →	+0.147	+2.026	.014	.005	3	3
UCEC	ATM →	-0.633	-2.000	<.001	.010	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.385	-3.321	.013	.009	2	3
SKCM	p90 RSK →	+0.251	+2.000	.007	.031	3	2
SKCM	STAT3_pY705 →	-0.241	-2.000	.047	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

SYT3 survival (RNA) · tumor vs normal (RNA) · all SYT3 data types