Across TCGA cell cohorts, SYT3 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT3-associated genes across cancer lineages are MARCHF11, GKN2, and DCD. Each is linked with SYT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT3-to-partner and partner-to-SYT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT3→partner) and Y-score (partner→SYT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MARCHF11 →	+0.355	+3.793	<.001	.007	3	2
CNS	GKN2 →	+0.200	+4.169	<.001	.008	3	1
LUNG_SCLC	DCD →	+0.868	+4.058	.001	.007	3	1
LUNG_SCLC	DPPA3 →	+0.039	+4.684	<.001	<.001	3	1
LUNG_SCLC	KRTAP4-6 →	+0.042	+4.058	<.001	.007	3	1
BLOOD_Lymphoma	OXT →	+0.040	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

SYT3 survival (RNA) · tumor vs normal (RNA) · all SYT3 data types