SYT2

Across TCGA patient cohorts, SYT2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT2-associated genes across cancer lineages are N-Ras, C-Raf_pS338, and FoxM1. Each is linked with SYT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT2-to-partner and partner-to-SYT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Ras grouped by SYT2-low versus SYT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT2→partner) and Y-score (partner→SYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Ras →	-0.098	-1.893	.040	.016	3	2
UCEC	C-Raf_pS338 →	-0.136	-2.415	<.001	.003	3	2
UCEC	FoxM1 →	+0.233	+1.906	.025	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-1.893	.003	.016	3	1
UCEC	Ku80 →	+0.257	+1.920	.006	.009	3	1
UCEC	MEK1_p_S217_S221 →	-0.235	-2.000	.032	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

N-Ras by SYT2 expression — UCEC

Explore this box plot interactively →