SYT2

Across TCGA cell cohorts, SYT2 mutation is significantly associated with the RNA expression of many other genes, with 283 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT2-associated genes across cancer lineages are GCAT, CBY1, and SLC25A17. Each is linked with SYT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT2-to-partner and partner-to-SYT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by SYT2-low versus SYT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT2→partner) and Y-score (partner→SYT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.463	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.743	+3.299	<.001	.004	3	1
LARGE_INTESTINE	SLC25A17 →	+0.635	+3.212	.003	.006	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.702	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PHF5A →	+0.507	+3.212	.008	.006	3	1
LARGE_INTESTINE	ADNP2 →	+0.741	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 283 associations by consensus.

GCAT by SYT2 expression — LARGE_INTESTINE

Explore this box plot interactively →