SYT16

Across TCGA pan-cancer cohorts, SYT16 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYT16 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SYT16 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SYT16 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SYT16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.633	0.927	.002	52	view →
CCRCC	DFS	Median	II,III,IV	0.966	0.211	.008	24	view →
PDAC	DFS	Quartile	All	0.696	0.243	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SYT16–HNSC (OS)

Open the HNSC breakdown →