SYT16

Across TCGA patient cohorts, SYT16 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT16-associated genes across cancer lineages are eEF2, ERK2, and MEK1. Each is linked with SYT16 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT16-to-partner and partner-to-SYT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SYT16-low versus SYT16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT16→partner) and Y-score (partner→SYT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.264	+1.906	.012	.014	3	4
SKCM	ERK2 →	+0.171	+1.925	.023	.004	3	3
UCEC	MEK1 →	+0.450	+2.099	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.543	+1.432	.001	.005	3	3
LUSC	eIF4E →	+0.181	+2.816	.030	.036	2	3
SKCM	p27_pT157 →	+0.142	+2.536	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by SYT16 expression — UCEC

Explore this box plot interactively →