SYT16

Across TCGA cell cohorts, SYT16 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT16-associated genes across cancer lineages are TBX22, KLRF2, and SIGLEC8. Each is linked with SYT16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT16-to-partner and partner-to-SYT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX22 grouped by SYT16-low versus SYT16-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT16→partner) and Y-score (partner→SYT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBX22 →	+0.036	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUSC	KLRF2 →	+0.193	+4.643	<.001	.008	3	1
OESOPHAGUS	SIGLEC8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4F15 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	NANOGNB →	+0.053	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CALHM4 →	+0.030	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

TBX22 by SYT16 expression — SOFT_TISSUE

Explore this box plot interactively →