SYT14

Across TCGA patient cohorts, SYT14 mutation is significantly associated with the RNA expression of many other genes, with 3,554 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT14-associated genes across cancer lineages are SNRPCP14, LINC02548, and EXOSC8. Each is linked with SYT14 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT14-to-partner and partner-to-SYT14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPCP14 grouped by SYT14-low versus SYT14-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT14→partner) and Y-score (partner→SYT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRPCP14 →	+0.243	+3.164	<.001	.003	3	3
SKCM	LINC02548 →	+0.625	+4.408	<.001	.005	3	3
UCEC	EXOSC8 →	+0.494	+2.828	<.001	<.001	3	3
UCEC	PIGW →	+0.500	+2.126	.001	<.001	3	2
CESC	HMX3 →	+0.708	+3.975	<.001	.006	3	2
CESC	NF1P6 →	+0.188	+5.927	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,554 associations by consensus.

SNRPCP14 by SYT14 expression — SKCM

Explore this box plot interactively →