SYT11

Across TCGA patient cohorts, SYT11 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT11-associated genes across cancer lineages are Gab2, STAT3_pY705, and c-Met_pY1235. Each is linked with SYT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT11-to-partner and partner-to-SYT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by SYT11-low versus SYT11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT11→partner) and Y-score (partner→SYT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.260	+1.362	.039	.037	3	2
UCEC	STAT3_pY705 →	-0.453	-3.807	<.001	<.001	3	2
UCEC	c-Met_pY1235 →	+0.053	+1.687	.043	.013	3	2
UCEC	4E-BP1 →	+0.227	+1.614	.017	.041	3	2
UCEC	Cyclin-B1 →	+0.682	+2.392	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.662	.019	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Gab2 by SYT11 expression — UCEC

Explore this box plot interactively →