SYT11

Across TCGA cell cohorts, SYT11 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT11-associated genes across cancer lineages are NLRP13, DIRC1, and RLN3. Each is linked with SYT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT11-to-partner and partner-to-SYT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP13 grouped by SYT11-low versus SYT11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT11→partner) and Y-score (partner→SYT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NLRP13 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	DIRC1 →	+0.129	+4.887	<.001	.009	3	1
BREAST	RLN3 →	+0.102	+5.169	<.001	.005	3	1
BREAST	SLC22A6 →	+0.006	+5.781	<.001	.001	3	1
LARGE_INTESTINE	DYDC1 →	+0.040	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR6S1 →	+0.045	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NLRP13 by SYT11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →