SYT10

Across TCGA patient cohorts, SYT10 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SYT10-associated genes across cancer lineages are Cyclin-B1, FoxM1, and EGFR. Each is linked with SYT10 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT10-to-partner and partner-to-SYT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SYT10-low versus SYT10-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT10→partner) and Y-score (partner→SYT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.820	+3.169	<.001	.018	3	4
STAD	FoxM1 →	+0.512	+3.031	<.001	.017	3	3
UCEC	EGFR →	-0.218	-2.807	<.001	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.176	-2.459	.006	.018	3	3
UCEC	p62 Lck ligand →	+0.365	+2.087	.003	.005	3	3
SKCM	SETD2 →	-0.091	-1.064	.039	.045	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Cyclin-B1 by SYT10 expression — LUAD

Explore this box plot interactively →