SYT1

Across TCGA pan-cancer cohorts, SYT1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYT1 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SYT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYT1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where SYT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.317	0.917	.010	9	view →
LUAD	OS	Median	III,IV	0.476	0.821	.044	2	view →
GBM	DFS	Tertile	All	0.832	0.657	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SYT1–HNSC (DFS)

Open the HNSC breakdown →