SYT1

Across TCGA patient cohorts, SYT1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT1-associated genes across cancer lineages are 4E-BP1, FOXO3a, and HER3_pY1289. Each is linked with SYT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT1-to-partner and partner-to-SYT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SYT1-low versus SYT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT1→partner) and Y-score (partner→SYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.216	+3.321	.023	.009	3	3
SKCM	FOXO3a →	-0.094	-1.222	.011	.033	3	2
SKCM	HER3_pY1289 →	-0.091	-3.666	.002	.001	3	2
SKCM	p90 RSK →	+0.241	+2.906	<.001	.001	3	2
SKCM	PCNA →	+0.195	+2.700	.001	.005	3	2
SKCM	Rictor_pT1135 →	-0.111	-1.807	.026	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by SYT1 expression — UCEC

Explore this box plot interactively →