Across TCGA pan-cancer cohorts, SYS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYS1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SYS1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYS1 expression acts as an unfavorable survival marker.

CESC, UCEC, and CHOL are the cancer types where SYS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	30	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SYS1 tumor-vs-normal RNA expression · all SYS1 data types